Which Diseases Can Be Treated With Umbilical Cord Blood?

Cord Blood And Diseases

According to the International Cord Blood Society, "Discarding the cord blood at the time of birth as is commonly done in 99 percent of all deliveries doesn’t make any sense whatsoever. Each year approximately 9000 patients are diagnosed with diseases that can be treated with stem cells and nearly 70 percent of those in need of a stem cell transplant are unable to find a match."

Why cord blood?

  • Compared to bone marrow transplant, gathering cord blood poses no risk to either the mother or the new born. Also, it is less controversial than getting stem cells from embryos/placentas. Plus there is practically no difference between stem cells from cord blood and stem cells from the other two sources.
  • Cord blood banking cryopreserves the stem cells present in it. Umbilical cord blood is "a life saving source of stem cells that are a 100 percent biological match to the newborn."
  • Stem cells are easier to obtain can be collected shortly after your child is born.


Why stem cells?

  • Stem cells have the ability to divide a million times over and replenish other cells in the blood and immune system. Stem cells thus become out body’s repair system.
  • Stem cells are also able to differentiate into various types of body cells.
  • And in a healthy body, stem cells work tirelessly.
  • Given their unique abilities, stem cells can be used to treat more than 75 different diseases and conditions.
  • However, they also fall victim to diseases that attack the body, such as leukemia, and lose their function to divide and repair, and differentiate into different cell types. In such cases, new stem cells are needed.

List of diseases which can be treated with (cord blood) stem cells

Acute Leukemia’s:

Acute Lymphoblast Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Acute Biphenotypic Leukemia 
Acute Undifferentiated Leukemia

Chronic Leukemia’s:

Chronic Myelogenous Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Juvenile Chronic Myelogenous Leukemia (JCML) 
Juvenile Myelomonocytic Leukemia (JMML)

Myelodysplastic Syndromes:

Refractory Anemia (RA) 
Refractory Anemia with Ringed Sideroblasts (RARS) 
Refractory Anemia with Excess Blasts (RAEB) 
Refractory Anemia with Excess Blasts in Transformation (RAEB-T) 
Chronic Myelomonocytic Leukemia (CMML)

Stem Cell Disorders:

Aplastic Anemia (Severe)
Fanconi Anemia 
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Pure Red Cell Aplasia

Myeloproliferative Disorders:

Acute Myelofibrosis 
Agnogenic Myeloid Metaplasia (myelofibrosis) 
Polycythemia Vera 
Essential Thrombocythemia

Lymphoproliferative Disorders:

Non-Hodgkin’s Lymphoma 
Hodgkin’s Disease 

Phagocyte Disorders:

Chediak-Higashi Syndrome |
Chronic Granulomatous Disease 
Neutrophil Actin Deficiency 
Reticular Dysgenesis

Other Inherited Disorders:

Lesch-Nyhan Syndrome 
Cartilage-Hair Hypoplasia 
Glanzmann Thrombasthenia 
Inherited Platelet Abnormalities
Amegakaryocytosis / Congenital Thrombocytopenia
Inherited Metabolic Disorders
Mucopolysaccharidoses (MPS) 
Hurler’s Syndrome (MPS-IH) 
Scheie Syndrome (MPS-IS) 
Hunter’s Syndrome (MPS-II) 
Sanfilippo Syndrome (MPS-III) 
Morquio Syndrome (MPS-IV)
Maroteaux-Lamy Syndrome (MPS-VI)
Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII) 
Mucolipidosis II (I-cell Disease)
Krabbe Disease 
Gaucher’s Disease 
Niemann-Pick Disease 
Wolman Disease 
Metachromatic Leukodystrophy

Histiocytic Disorders:

Familial Erythrophagocytic Lymphohistiocytosis 

Inherited Erythrocyte Abnormalities:

Beta Thalassemia Major 
Sickle Cell Disease
Inherited Immune System Disorders
Kostmann Syndrome
Leukocyte Adhesion Deficiency 
DiGeorge Syndrome 
Bare Lymphocyte Syndrome 
Omenn’s Syndrome
Severe Combined Immunodeficiency (SCID) 
SCID with Adenosine Deaminase Deficiency
Absence of T & B Cells SCID 
Absence of T Cells, Normal B Cell SCID 
Common Variable Immunodeficiency 
Wiskott-Aldrich Syndrome
X-Linked Lymphoproliferative Disorder

Plasma Cell Disorders:

Multiple Myeloma 
Plasma Cell Leukemia 
Waldenstrom’s Macroglobulinemia

Other Malignancies:

Ewing Sarcoma 
Renal Cell Carcinoma
Potential Future Stem Cell Applications
Alzheimer’s Disease
Cardiac Disease
Multiple Sclerosis
Muscular Dystrophy
Parkinson’s Disease
Rheumatoid Arthritis
Spinal Cord Injury

Source: cordblood.org


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