Study Reveals Link Between Diet, Hormones, Metabolism, And Body Clock 

The body is a complicated set of different functions that scientists are still trying to grasp and understand even today. Even the way the body gains weight based on a different set of factors still remains to be a puzzle. But scientists as slowly uncovering the links between weight gain and diet, hormones, and body clock. 

A recent study by researchers from Helmholtz Zentrum Munchen and the German Center for Diabetes Research or DZD has revealed for the first time how stress hormones can control fat as well as sugar levels in a 24-hour period. The same study also showed how a diet high in calories can have an effect on the body’s metabolic cycles. The researchers in the said study are both based in Munich, Germany. 

The researchers were able to make the discoveries by studying the glucocorticoid activity in the livers of lab mice. The study was aimed to understand the connection between glucocorticoid receptors and daily surges in the stress hormones, the metabolic cycles, and the biological clock. Glucocorticoids are important in regulating a number of molecular processes in several bodily functions such as metabolism, cognition, metabolism, and even immunity. Almost every cell in the body has receptors that allow the said hormone to enter into cells and influence their functions.   

The researchers looked into the metabolic activity of the glucocorticoids in mice livers and evaluated the properties of the hormone’s matching receptors.  They used advanced methods of mapping out what happened to the glucocorticoid receptors in mouse livers for every four hours for a 24-hour period. One group of mice were studied while going on a normal diet. The other group was studied while following a high-fat diet. 

The researchers were able to show that the effects of glucocorticoids differ from when animals fasted during sleep and while they eat when they are active and awake. They found out that effect was the result of glucocorticoid receptors binding with the genomes of the liver cells. It also appears that the receptor associated with the stress hormones may play a role in regulating nearly all of the body’s circadian genes. The study indicates that mice livers that lacked the receptor did not regulate the fat and sugar levels according to day or night. The findings also indicate that the liver controls sugar and blood levels differently during night and day. 

The researchers believe that the said study is the first to show how one’s diet can change the effects of hormones and drugs on metabolic tissues. They further added that the findings may eventually help provide essential data in the relatively new field of chronomedicine where the body’s biological clock plays a large role in health and disease. The findings of the said study were recently published in Molecular Cell.  

Source: Medical News Today 

 

Tags: , ,